The 1-letter or 1-number approach is only the first relation you can use. You can read more about it at mixedinkey.com/book (in the advanced section) but I’ll provide a summary.
Sometimes you want an abrupt key change to have a sudden change in mood. It doesn’t work with all tracks, but try doing a +4 (ie 4A to 8A). Also, if you want to go from A to B, you can also try stepping up the number (1A to 2B or 2B to 1A, but not 1B to 2A/2A to 1B).
Also, the quick relation for semitones is such:
One semitone up -> Add 7
Two semitones up -> Add 2
Some of these are hit and miss (best trying at home rather than playing out), but it should give you a little flexibility. I’d advise against long blends when there is a sudden key shift, however. Stick with 8 – 16 bars.
Edit: I just wanted to add that sudden-key shifts should be used sparingly. It dulls the impact/annoys the ear if you’re doing it too much.