It is a tricky one.
If it is the eq on the input channels of the house mixer I usually leave them at 0 (12 o’clock) and do all my eq-ing from my mixer/controller.
If it is the EQ on the output channels of the house mixer they may just be set to adjust for the room acoustics and touching them might turn out to be a really bad idea. If you are a venue owner you preferably want to “sound out” a room and have output EQ (parametric) to compensate for the acoustics and then lock and seal those.
“They are active and have their own mixer” … sounds like the speakers have their own eq built-in. If that is the case, they are probably 2 or 3-band regular (not parametric) tone control and totally unsuited for room compensation. So I would leave them at 0 and do everything from your controller/mixer.
If, like Terry, you plan on doing a sound check, keep in mind that an empty room sounds completely different from the same room filled with people :), so make sure to do a quick run through the house once the crowd is in to make any adjustments.
Greetinx,
C.