Im in no way a sound engineer or an expert, but I think sound quality in volume depends on how the signal is amplified.
I mean: Virtual DJ, or any DJ software amplifies the sound digitally. Its as if you turn up the gain of a track. It sounds distorted, then you balance it with your master out to make it sound neat.
The longer the signal path is, the more devices you have to sync. But in my opinion, you should control your volume in a more analog way, in an amplifier, the mixer or the audio card, and leave the master out of your digital dj software at a level where it can be heard but it doesnt amplify the sound in a big amount.
I may stand correct or 100% wrong.