Well, you came to the right place! Co-moderator Terry_42 is an avid Reloop TM8/Serato user. Plays out frequently with this setup and as far as I know, trouble-free. I am sure he can put your mind at ease.
Might have to wait a day or two before you get a response though as I believe he is taking a few days off from the forum due to some other pressing matters.
So, hold tight. Help is on the way.
On a general note: If hardware works well and then starts acting up because someone changes something in the software, you can’t really blame the hardware, can you? Let’s say you’d switch to a Pioneer DDJ-SX2 and it works real well with Serato and two Serato upgrades down the line it starts having problems, what do you do? Do you buy yet another piece of hardware to work well with the software? Or do you knock on the door of the software and tell them to get their stuff in order?
Are there any other possibly contributing factors, like upgrading Mac to El Capitan or Windows to version 10 recently?