Not currently with the DJIO – whilst Mixx, Traktor, Cross & Virtual DJ work without limitations when it comes to getting audio out, Serato either has to be used with a certified controller (many examples out there), certified mixer (with a soundcard in it) or a certified soundcard (at the moment, only the Rane SL2, SL3 and SL4 are listed on their website – although I am fairly sure that the Denon DS1 is also compatible – https://serato.com/dj/hardware/mixers-interfaces).
Without a certified bit of hardware connected, Serato is limited to just 1 deck along with various other limitations – making is useless for DJing live with and pretty much only good for prepping your tracks..
Hope that helps,
bob6397